Applications of Biotechnology in Neurology - download pdf or read online

By Kewal K. Jain

ISBN-10: 1627032711

ISBN-13: 9781627032711

ISBN-10: 162703272X

ISBN-13: 9781627032728

Culling jointly excerpts from quite a lot of writings through Dr. Kewal ok. Jain on biotechnology themes as they relate to issues of the fearful process, Applications of Biotechnology in Neurology covers numerous purposes for these operating in lifestyles sciences and the pharmaceutical sciences, really these constructing diagnostics and therapeutics for the worried process. This precise quantity delves into components comparable to neurobiotechnology, like neurogenomics and neuroproteomics, molecular diagnostics, a variety of tools of enhancing systemic management of substances for specified supply to the anxious method, together with using nanobiotechnology, biotechnology-based options and items for neuroprotection, in addition to chapters on neurosurgery and customized neurology.

Thorough, state-of-the-art, and thoughtfully geared up, Applications of Biotechnology in Neurology serves as a fantastic consultant, supplemented by means of seventy five tables and sixteen figures in addition to various references from fresh literature in this subject, that are appended to every chapter.

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Some will be described briefly in the following text and a few important ones have full chapters devoted to them. 2 Applications of neurogenomics Applications in basic neurosciences Molecular neuropathology Study of genes for neurological disorders Genomic studies of non-human organisms relevant to neurology Study of gene expression in the nervous system Creation of transgenic models of neurological disorders Application in drug discovery and development Molecular neuropharmacology Discovery of targets for new drugs for neurological disorders Gene therapy Development of personalized medicines for neurological disorders Clinical applications in neurology Redefinition and reclassification of diseases Discovery of biomarkers Molecular diagnostics Integration of diagnostics and therapeutics © Jain PharmaBiotech Molecular Neuropathology Genomic technologies have enabled the study of neuropathology at the molecular level; this may be termed molecular neuropathology.

Genotyping can be performed both before and after therapy, whereas therapeutic drug monitoring is performed in conjunction with therapy. • Genotyping can identify any gene, whereas therapeutic drug monitoring identifies only metabolic variations. g. those in ion channel genes. Future drugs may be designed specifically according to the electrophysiological dysfunction as personalized medicines for epilepsy. Study of multidrug transporters is a fruitful area of epilepsy research. The knowledge that multidrug transporters are increased in epileptogenic areas opens potential new avenues for therapeutic intervention.

3 Classification of calcium ion channels ......................................... 230 Ligand- and transmitter-gated ion channels ................................. 232 Drugs targeting ion channels used for the treatment of neurologic disorders................................................................. 2 Selected neurological applications of NO-based therapies .......... 255 Drugs with beneficial effect on cerebral ischemia mediated through NO ...................................................................

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Applications of Biotechnology in Neurology by Kewal K. Jain


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