Read e-book online Advances in Cancer Biomarkers: From biochemistry to clinic PDF

By Roberto Scatena

ISBN-10: 9401772142

ISBN-13: 9789401772143

ISBN-10: 9401772150

ISBN-13: 9789401772150

At current there are an increasing number of biomolecules lower than research to appreciate their capability function as melanoma biomarker for diagnostic, prognostic and healing reasons. Intriguingly, the kingdom of artwork on melanoma biomarkers learn exhibits fascinating and promising effects jointly to clamorous mess ups. additionally from a medical perspective, there are contradictory effects on regimen medical use of the current melanoma biomarkers. a few sufferers could be easily monitored of their direction by way of a periodic blood pattern, yet occasionally this tracking indicates dramatic limits. loads of sufferers convey critical and huge relapses with no major swap in serum concentrations of biomarkers validated. frequently the health care provider who may still make the most of those biomarker doesn't totally recognize their limits and the entire capability functions in addition and occasionally this data is motivated via cost effective and advertising options. This constrained and “polluted” wisdom could have dramatic results for sufferer. the purpose of this booklet is to diffuse all features of melanoma biomarkers, from their biochemical peculiarities to all scientific implications through passing via their body structure and pathophysiology.

This serious method in the direction of outdated and new melanoma biomarkers should still foster a deepened and necessary realizing of the diagnostic and prognostic index of those primary parameters of laboratory medication and within the similar time facilitating the study of recent and extra sensitive-specific signs of the melanoma mobilephone proliferation.

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Genome Med 5(8):73. 1186/gm477 Ignatiadis M, Dawson SJ (2014) Circulating tumor cells and circulating tumor DNA for precision medicine: dream or reality? Ann Oncol 25(12):2304– 2313. 1093/annonc/mdu480 Cheng G (2014) Circulating miRNAs: roles in cancer diagnosis, prognosis and therapy. Adv Drug Deliv Rev. 001 Hayes J, Peruzzi PP, Lawler S (2014) MicroRNAs in cancer: biomarkers, functions and therapy. 107. 108. 109. 110. Trends Mol Med 20(8):460–469. 1016/j. 005 Shen J, Stass SA, Jiang F (2013) MicroRNAs as potential biomarkers in human solid tumors.

The “holy grail” of a simple blood test for the early detection of cancer therefore remains. Indeed, the question needs to be addressed whether the measurement of a single biomarker in serum can provide a reliable test for the early detection of cancer. Small or surgically resectable cancers are likely to release relatively low concentrations of biomarkers into blood. This, coupled with the large dilution in blood following release, presents a major challenge in devising assays to detect biomarker levels above background.

Henry NL, Hayes DF (2012) Cancer biomarkers. Mol Oncol 6(2):140–146. 1016/j. 010 11. Paoletti C, Hayes DF (2014) Molecular testing in breast cancer. Annu Rev Med 65:95–110. 1146/annurev-med-070912-143853 12. Buyse M, Michiels S, Sargent DJ, Grothey A, Matheson A, de Gramont A (2011) Integrating biomarkers in clinical trials. Expert Rev Mol Diagn 11(2):171–182. 120 13. Duffy MJ, Crown J (2008) A personalized approach to cancer treatment: how biomarkers can help. Clin Chem 54(11):1770–1779. 110056 14.

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Advances in Cancer Biomarkers: From biochemistry to clinic for a critical revision by Roberto Scatena

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