Read e-book online ABC Transporters and Cancer PDF

By Toshihisa Ishikawa, John Schuetz

ISBN-10: 0128013613

ISBN-13: 9780128013618

ABC Transporters and Cancer offers important info at the fascinating and fast-moving box of melanoma learn. the following, awesome and unique stories are offered on a number of issues. This quantity covers ABC transporters and melanoma, and is acceptable for researchers and scholars alike.

  • Provides details on melanoma research
  • Outstanding and unique reviews
  • Suitable for researchers and students
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    Extra info for ABC Transporters and Cancer

    Sample text

    Cyclosporin A and valspodar are more modest inhibitors, resulting in lower uptake rates (Bardelmeijer, Ouwehand, Beijnen, Schellens, & van Tellingen, 2004). , 2014). Elacridar boosting was studied not only in mice but also in rats. , 2010). The boosting effect of elacridar is much more pronounced compared to the bioavailability after oral coadministration of paclitaxel with herbal extracts (~ 6–9%), Therefore, oral coadministration of taxanes with the Abcb1a/1b inhibitor elacridar seems a feasible approach to increase the oral bioavailability of taxanes.

    2012). There were differences in the ABCG2-overexpressing cell lines (Saos-2 or MDCKII cells), type of transport assay (cellular accumulation or transepithelial transport), and specific inhibitors (none or Ko143) used. Based on our own experience, we consider transepithelial transport assays, complemented with the use of relatively “specific” inhibitors, as one of the more sensitive in vitro probes for testing hydrophobic ABC transporter substrates. Conflicting findings were also reported by Shibayama et al.

    Following uptake, 5-FU is anabolized to nucleosides then nucleotides. While there are well-known mechanisms of enzymatic resistance to 5-FU, the role of transporters in 5-FU resistance is just beginning to be appreciated. This review summarizes the current knowledge on the role of drug transporters with particular focus on ABC transporters in fluoropyrimidine-based chemotherapy response. We would like to thank all those who have made this volume possible, especially Ms. Camille Miller Doty, Sarah Lay, and members of the “Schuetz labs” (Satish Cheepala, John Lynch, Jessie Morgan, Yu Fukuda, Aaron Pitre).

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    ABC Transporters and Cancer by Toshihisa Ishikawa, John Schuetz

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